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Accutane, or Isotretinoin, or Roaccutane for parts of the world, was discovered in 1979 when it was first given to patients with severe acne. They showed dramatic and permanent clearing of their acne symptoms.

Accutane is a vitamin A derivative taken orally in pill form, normally for 15-20 weeks. It was originally prescribed for people with severe acne that did not respond to other treatment. It has gain popularity in the past 25 years and is prescribed today more and more frequently for less severe acne. Quite a controversial practice, since Accutane is a strong drugs and may cause serious side effects. How Accutane exactly works is unknown, but what is known well is that it affects acne development.

Accutane dramatically reduces the size of the skin's oil glands, up to 58%. It even more dramatically reduces the amount of oil the skin produces, up to 80%. Therefore the amount of acne bacteria that live in skin oil are also reduced.

Accutane slows down the skin cells production inside the pore, which helps to keep pores from becoming clogged.

Though acne may get worse within the first month of Accutane course, the ultimate results are usually dramatic. Most people taking Accutane see their face effectively cured. About 95% of people who complete a cycle show partial or complete clearance of their acne, regardless of whether they have inflammatory or non-inflamatory acne.

Do not take any supplement containing vitamin A if you are on Accutane medication. Do not donate blood while taking Accutane, until at least 30 days after you stop taking it. Do not take Accutane either if you are allergic to isotretinoin or parabens.

Tell your doctor if you have any of these conditions: - A history of depression or mental illness - Heart disease - High cholesterol - Osteoporosis or other bone disorders - Diabetes - Asthma or other breathing problems - Anorexia nervosa - Liver disease